Yes, if your circumstances adjust. This is called an offer of commitment (OIC). Generally, the IRS will only settle for what it thinks you can affordably pay. To determine this, you'll consider your assets (home, car, etc.).
You can negotiate your back taxes with the IRS. You can't get rid of them, but you can come to an agreement on an equitable, reasonable, or possible way to pay them. The worst thing you can do right now is to ignore everything in the hope that the problem will go away. The IRS sometimes considers reaching an agreement that allows you to pay a reduced amount of what you owe in back taxes, called a compromise offer.
You must convince the IRS that you cannot pay what you owe and offer to pay the reduced amount in a lump sum or in short-term installments. Even if the IRS attempts to collect a tax debt, the taxpayer can file collection resources to try to stop a tax lien, lien, or seizure before the statute of limitations expires. You should consult a certified tax resolution specialist or a lawyer who specializes in tax debt relief to discuss your options and negotiate a payment plan with the IRS. If you owe back taxes and you still don't know where to start or are worried about dealing with the IRS, contact Top Tax Defenders.